Publications

Mechanical force-induced tissue remodeling in a clinically relevant microphysiological model of asthmatic human lungs

Paek J, Teegala LR, Alisafaei F, Alim A, Song JW, Park SE, Chang J, Liu H et al.

Nature Biomedical Engineering, published online May 11, 2026

A Convergent uPAR-Positive Tumor Ecosystem Creates Broad Vulnerability to CAR T Cell Therapy

Zhang Z, Ho Y-J, Fang X, Kim M, Li M, Luan W, Hinterleitner C, Haubner S, Kogel F, Pratt EC, Ozcelik E, Reyes J, Jiang Q, Yang VW, Chen Y-J, Wang T, Liu H et al.

Cell, 189, 2898-2917.e42, 2026

A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors

Liu H, Noguera-Ortega E, Dong X, Lee WD, Chang J, Aydin SA, Li Y, Shin Y, Shi X, Liousia M, Martinez MC, Brotman JJ, Kim S, Chen Z, Wang A, Ou Z, Paek J, Park JY, Liu A, Hu H, Xiao Z, Racca DM, Kim S, Worthen GS, Guo W, Pure E, Kang T, Rabinowitz JD, Wherry EJ, Moon EK, Albelda SM, and Huh D

Nature Biotechnology, 44, 959-975, 2026

Front Cover.

A bioengineered model of the human cornea for preclinical assessment of human ocular exposure to environmental toxicants

Kim S, Guo N, Tan ZY, Gao X, Fattahi P, Liu H et al.

Advanced Healthcare Materials, 2402408, 2025

The use of a multi-metric readout screen to identify EHMT2/G9a-inhibition as a modulator of cancer-associated fibroblast activation state

Wu N, Quevedo R, Nurse M, Hezaveh K, Liu H et al.

Biomaterials, 314, 122879, 2024

Combinatorial Screen of Dynamic Mechanical Stimuli for Predictive Control of MSC Mechano-Responsiveness

Liu H, Usprech J, Parameshwar PK, Sun Y and Simmons CA

Science Advances, 7 (19), eabe7204, 2021

A Microdevice Platform for Characterizing the Effect of Mechanical Strain Magnitudes on the Maturation of iPSC-Cardiomyocytes

Dou W, Wang L, Malhi M, Liu H et al.

Biosensors and Bioelectronics, 175, 112875, 2021

Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions

Moyle L, Cheng R, Liu H, et al.

Molecular Biology of the Cell, mbc.E20-01-0078, 2020

Microdevice Platform for Continuous Measurement of Contractility, Beating Rate, and Beating Rhythm of Human-Induced Pluripotent Stem Cell-Cardiomyocytes inside a Controlled Incubator Environment

Wang L, Dou W, Malhi M, Zhu M, Liu H et al.

ACS Applied Materials & Interfaces, 10 (25), 21173-21183, 2018

Microdevice Arrays with Strain Sensors for 3D Mechanical Stimulation and Monitoring of Engineered Tissues

Liu H, MacQueen L, Usprech J et al.

Biomaterials, 172, 30-40, 2018

Mechanical stability of the cell nucleus: roles played by the cytoskeleton in nuclear deformation and strain recovery

Wang X, Liu H, Zhu M, Cao C et al.

Journal of Cell Science, 131 (13), jcs.209627, 2018

Cell Contractility and Tissue Tension Coregulate Fgfr2-dependent Tetrads and Rosettes in the Mouse Embryo

Wen J, Lau K, Tao H, Liu H et al.

Biophysical Journal, 112, 2209-2218, 2017

Automated Robotic Measurement of 3D Cell Morphologies

Liu J, Zhang Z, Wang X, Liu H et al.

IEEE Robotics and Automation Letters, 2 (2), 499-505, 2016

A Microfabricated Platform with Hydrogel Arrays for 3D Mechanical Stimulation of Cells

Liu H, Usprech J, Sun Y, Simmons CA

Acta Biomaterialia, 34, 113-124, 2016

Voyage inside the cell: Microsystems and nanoengineering for intracellular measurement and manipulation

Liu J, Wen J, Zhang Z, Liu H, Sun Y

Microsystems & Nanoengineering, 1, 15020, 2015

Nature sponsored journal.

Polyacrylamide Gel Substrates that Simulate the Mechanical Stiffness of Normal and Malignant Neuronal Tissues Increase Protoporphyin IX Synthesis in Glioma cells

Niu CJ, Fisher C, Scheffler K, Wan R, Maleki H, Liu H et al.

Journal of Biomedical Optics, 20, 098002, 2015

Anisotropic stress orients remodeling of limb bud ectoderm

Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N et al.

Nature Cell Biology, 17, 569-579, 2015

Automated Vitrification of Embryos: A Robotics Approach

Liu J, Shi C, Wen J, Pyne D, Liu H, Ru C et al.

IEEE Robotics & Automation Magazine, 22, 33-40, 2015

In Situ Mechanical Characterization of the Cell Nucleus by Atomic Force Microscopy

Liu H*, Wen J*, Xiao Y, Liu J, Hopyan S, Radisic M et al.

ACS Nano, 8, 3821-3828, 2014

Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle

Xiao Y, Zhang B, Liu H et al.

Lab on a Chip, 5, 869-882, 2014

Front Cover; top 10%; Hot Article.

Determination of Local and Global Elastic Moduli of Valve Interstitial Cells Cultured on Soft Substrates

Liu H, Sun Y, Simmons CA

Journal of Biomechanics, 46, 1967-1971, 2013

Biophysical Characterization of Bladder Cancer Cells with Different Metastatic Potential

Liu H*, Tan Q*, Geddie WR et al.

Cell Biochemistry and Biophysics, 2, 241-246, 2013

Perfusable branching microvessel bed for vascularization of engineered tissues

Chiu LLY, Montgomery M, Liang Y, Liu H, et al.

Proceedings of the National Academy of Sciences of the USA, 109, E3414-E3423, 2012