iTES Laboratory
Intelligent Tissue Engineering and Systems Laboratory
Lab Overview
Our research centers on developing human-centric and predictive microphysiological systems at the interface of tissue engineering, microfluidics, and translational medicine, to address technical barriers to progress in human biology and accelerate next-generation therapeutics.
Research Highlight
We present a microengineered system that enables vascularization of human solid tumor explants and their controlled perfusion with immune cells to model the activity of CAR-T cells in the tumor microenvironment. This system supports real-time analysis of tumor-CAR-T dynamics, evaluation of engineering strategies, and identification of druggable targets to promote CAR-T cell efficacy.
Fig. 1: Microengineered system for in vitro transplantation and prolonged maintenance of human solid tumors.
Fig. 2: In vitro modeling of CAR-T-tumor interactions.
Fig. 3: Flow cytometric analysis of CAR-T cell phenotype and scRNA-seq analysis of microengineered tumor model.
Fig. 4: In vitro and in vivo analysis of human meso-CAR-T cells armored with CCR2.
Fig. 5: Transplantation and CAR-T cell treatment of human mesothelioma explants.
Fig. 6: Identification of therapeutic targets through analysis of ligand-receptor interactions in CAR-T cell-treated tumor models.
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